MovDisordV3, Main, Exploration, bibRecord, 003432

Family‐based case–control study of MAOA and MAOB polymorphisms in Parkinson disease

Identifieur interne : 003432 ( Main/Exploration ); précédent : 003431; suivant : 003433

Family‐based case–control study of MAOA and MAOB polymorphisms in Parkinson disease

Auteurs : Sun J. Kang [États-Unis] ; William K. Scott [États-Unis] ; Yi-Ju Li [États-Unis] ; Michael A. Hauser [États-Unis] ; Joelle M. Van Der Walt [États-Unis] ; Kenichiro Fujiwara [États-Unis] ; Gregory M. Mayhew [États-Unis] ; Sandra G. West [États-Unis] ; Jeffery M. Vance [États-Unis] ; Eden R. Martin [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-12.

RBID : ISTEX:F5A10EB001E33C6DB921F3F2610F89C2719BEF62

Descripteurs français

Pascal (Inist)
- Etude cas témoin, Etude familiale, Parkinson maladie, Polymorphisme, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Aged, Case control study, Case-Control Studies, Chromosomes, Human, X, Confidence Intervals, Family Health, Family study, Female, Humans, Linkage Disequilibrium, MAOA, MAOB, Male, Middle Aged, Monoamine Oxidase (genetics), Nervous system diseases, Odds Ratio, PD, Parkinson Disease (genetics), Parkinson disease, Polymorphism, Polymorphism, Genetic, Sex Factors, family‐based association.
MESH :
- chemical , genetics : Monoamine Oxidase.
- genetics : Parkinson Disease.
- Adult, Aged, Case-Control Studies, Chromosomes, Human, X, Confidence Intervals, Family Health, Female, Humans, Linkage Disequilibrium, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic, Sex Factors.

Abstract

Monoamine oxidase (MAO) is an enzyme regulating metabolism of neurotransmitters such as dopamine. Two distinct forms of enzyme, encoded by genes MAOA and MAOB located on the X chromosome, have been considered as possible factors in the pathogenesis of Parkinson disease (PD). Previous association studies of PD and MAO genes reported inconsistent results. In this study, we used a large family‐based data set to test associations between MAO genes and a risk of PD. The data set includes 298 female discordant sibpairs and 348 male discordant sibpairs. For this study, all subjects analyzed were white and families with known parkin mutations were removed. We analyzed 15 single nucleotide polymorphisms (SNPs) and a dinucleotide repeat marker in the MAO genes. Association was found with the intron 13 SNP of MAOB in the female subset (P = 0.02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/F5A10EB001E33C6DB921F3F2610F89C2719BEF62/fulltext/pdf

DOI: 10.1002/mds.21151

Affiliations:

Le document en format XML

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<author><name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A." last="Hauser">Michael A. Hauser</name>
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<author><name sortKey="Fujiwara, Kenichiro" sort="Fujiwara, Kenichiro" uniqKey="Fujiwara K" first="Kenichiro" last="Fujiwara">Kenichiro Fujiwara</name>
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<author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
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<term>Aged</term>
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<term>Case-Control Studies</term>
<term>Chromosomes, Human, X</term>
<term>Confidence Intervals</term>
<term>Family Health</term>
<term>Family study</term>
<term>Female</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>MAOA</term>
<term>MAOB</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Monoamine Oxidase (genetics)</term>
<term>Nervous system diseases</term>
<term>Odds Ratio</term>
<term>PD</term>
<term>Parkinson Disease (genetics)</term>
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<term>Polymorphism</term>
<term>Polymorphism, Genetic</term>
<term>Sex Factors</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Chromosomes, Human, X</term>
<term>Confidence Intervals</term>
<term>Family Health</term>
<term>Female</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Polymorphism, Genetic</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etude cas témoin</term>
<term>Etude familiale</term>
<term>Parkinson maladie</term>
<term>Polymorphisme</term>
<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">Monoamine oxidase (MAO) is an enzyme regulating metabolism of neurotransmitters such as dopamine. Two distinct forms of enzyme, encoded by genes MAOA and MAOB located on the X chromosome, have been considered as possible factors in the pathogenesis of Parkinson disease (PD). Previous association studies of PD and MAO genes reported inconsistent results. In this study, we used a large family‐based data set to test associations between MAO genes and a risk of PD. The data set includes 298 female discordant sibpairs and 348 male discordant sibpairs. For this study, all subjects analyzed were white and families with known parkin mutations were removed. We analyzed 15 single nucleotide polymorphisms (SNPs) and a dinucleotide repeat marker in the MAO genes. Association was found with the intron 13 SNP of MAOB in the female subset (P = 0.02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women. © 2006 Movement Disorder Society</div>
</front>
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<name sortKey="Fujiwara, Kenichiro" sort="Fujiwara, Kenichiro" uniqKey="Fujiwara K" first="Kenichiro" last="Fujiwara">Kenichiro Fujiwara</name>
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<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
<name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name>
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<name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K." last="Scott">William K. Scott</name>
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<name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M." last="Vance">Jeffery M. Vance</name>
<name sortKey="West, Sandra G" sort="West, Sandra G" uniqKey="West S" first="Sandra G." last="West">Sandra G. West</name>
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Movement Disorders (revue)

Family‐based case–control study of MAOA and MAOB polymorphisms in Parkinson disease

Family‐based case–control study of MAOA and MAOB polymorphisms in Parkinson disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.